|本期目录/Table of Contents|

 SONG Cui,ZHANG Xiao,WEI Wei,et al.Application of atomic force microscopy in measuring particle-cell interactions[J].Chinese Journal of Bioprocess Engineering,2019,17(01):53-59.[doi:10.3969/j.issn.1672-3678.2019.01.008]





Application of atomic force microscopy in measuring particle-cell interactions
1. 中国科学院 过程工程研究所 生化工程国家重点实验室,北京 100190; 2.中国科学院大学,北京 100049
SONG Cui12ZHANG Xiao1WEI Wei12MA Guanghui12
1. State Key Laboratory Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China; 2. University of Chinese Academy of Sciences,Beijing 100049,China
原子力显微镜 纳微颗粒 颗粒-细胞相互作用 生物医药
凭借独特的尺寸效应和理化性质,纳微颗粒在生物医药领域的应用日益广泛,其与细胞的相互作用也备受关注,对其进行定量测量和机制研究愈发重要。目前,原子力显微镜(atomic force microscopy,AFM)由于具有高灵敏度(皮牛级)、高分辨率(纳米级)以及在生理环境中可进行实时检测等优势成为检测颗粒与细胞相互作用的重要工具。利用AFM检测颗粒与细胞相互作用,有助于确定作用过程中的重要参数,解释颗粒在药物递送、免疫响应和细胞力学等应用方面深层次的机制。本文中,笔者就原子力显微镜检测颗粒与细胞相互作用及其应用进行系统的综述,并对其未来的发展方向进行展望。


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 DU Xiaonan,LI Yan,SUN Lijing,et al.Measurement and Characterization of the Agglomeration of Multimeric Proteins on Solid-liquid Interface[J].Chinese Journal of Bioprocess Engineering,2012,10(01):51.[doi:10.3969/j.issn.1672-3678.2012.01.010]


作者简介:宋翠(1982—),女,山东济南人,博士研究生,研究方向:生物工程; 魏炜(联系人),研究员,E-mail:weiwei@ipe.ac.cn; 马光辉(联系人),研究员,E-mail:ghma@ipe.ac.cn
SONG Cui,ZHANG Xiao,WEI Wei,et al.Application of atomic force microscopy in measuring particle-cell interactions[J].Chin J Bioprocess Eng,2019,17(1):53-59..
更新日期/Last Update: 2019-01-30