|本期目录/Table of Contents|

[1]仪明君,宋广亮,朱红军,等.面包酵母催化不对称合成4-氯-(R)-3-羟基丁酸乙酯[J].生物加工过程,2005,3(02):27-30.[doi:10.3969/j.issn.1672-3678.2005.02.006]
 YI Ming-jun,SONG Guang-liang,ZHU Hong-jun,et al.Asymmetric synthesis of ethyl 4-Chloro-(R)-3-hydroxybutyrate with baker′s yeast[J].Chinese Journal of Bioprocess Engineering,2005,3(02):27-30.[doi:10.3969/j.issn.1672-3678.2005.02.006]
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面包酵母催化不对称合成4-氯-(R)-3-羟基丁酸乙酯()
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
3
期数:
2005年02期
页码:
27-30
栏目:
出版日期:
2005-05-30

文章信息/Info

Title:
Asymmetric synthesis of ethyl 4-Chloro-(R)-3-hydroxybutyrate with baker′s yeast
作者:
仪明君宋广亮朱红军王锦堂
南京工业大学, 应用化学系, 南京, 210009
Author(s):
YI Ming-jun SONG Guang-liang ZHU Hong-jun WANG Ji-tang
关键词:
面包酵母生物催化不对称还原4-氯乙酰乙酸乙酯4-氯-(R)-3-羟基丁酸乙酯
分类号:
TQ925
DOI:
10.3969/j.issn.1672-3678.2005.02.006
摘要:
以4-氯乙酰乙酸乙酯为原料,以面包酵母为手性生物催化剂,选择性合成光学活性4-氯-(R)-3-羟基丁酸乙酯.经IR、GC-MS、1HNMR和旋光度测定,表明所得产品的结构与预期的结构一致.分别考察了面包酵母用量、葡萄糖浓度、底物投入量、pH值、反应时间以及反应温度等因素对产品比旋光度的影响.结果表明,4-氯乙酰乙酸乙酯不对称生物还原反应的适宜条件为:面包酵母600 g/L、葡萄糖20 g/L、反应温度34 ℃、底物加量16 mL/L、反应时间48 h、pH为5,产品的比旋光度为[α]20D=+13.9°.

参考文献/References:

[1] Yatagai OK. Process for asymmetrically reducing carbonyl compounds [P]. Japan JP88309645, 1988.
[2] Noyori R, Ohkuma T, Kitamura M. Asymmetry hydrogenation of β-keto carboxylic esters.a pactical, purely chemical access toβ-hydroxy esters in high enantiomaric purity [J]. Journal of the American Chemical Society, 1987, (19):5856-5858.doi:10.1021/ja00253a051.
[3] 张玉彬. 生物催化的手性合成 [M]. 北京:化学工业出版社, 2001.8.

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备注/Memo:
基金项目:国家科技攻关项目
更新日期/Last Update: 1900-01-01