|本期目录/Table of Contents|

[1]郑志永,关怡新,林东强,等.重组基因表达对大肠杆菌生理的影响[J].生物加工过程,2004,2(02):13.[doi:10.3969/j.issn.1672-3678.2004.02.003]
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重组基因表达对大肠杆菌生理的影响()
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
2
期数:
2004年02期
页码:
13
栏目:
出版日期:
2004-05-30

文章信息/Info

Title:
Effect of recombinant gene expression on physiological metabolism in Escherichia coli
作者:
郑志永关怡新林东强姚善泾
浙江大学, 化学工程与生物工程学系, 杭州, 310027
关键词:
基因表达代谢负荷发酵策略大肠杆菌
分类号:
Q786
DOI:
10.3969/j.issn.1672-3678.2004.02.003
摘要:
重组基因在表达外源蛋白质时常常会耗用大量的宿主细胞资源,从而对宿主造成代谢负荷,代谢负荷使得宿主的生化和生理产生很大的变化,甚至损害宿主正常的代谢功能.而过重的代谢负荷会影响目标蛋白的表达量和表达质量.综述了产生代谢负荷的原因,宿主细胞对代谢负荷的应激反应、以及减轻代谢负荷的策略.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金
更新日期/Last Update: 1900-01-01