|本期目录/Table of Contents|

[1]张军华.微生物发酵法生产L赖氨酸的研究进展[J].生物加工过程,2012,10(02):73-78.[doi:10.3969/j.issn.1672-3678.2012.02.015]
 ZHANG Junhua.Research progress on microbial fermentation of L-lysine[J].Chinese Journal of Bioprocess Engineering,2012,10(02):73-78.[doi:10.3969/j.issn.1672-3678.2012.02.015]
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微生物发酵法生产L赖氨酸的研究进展()
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
10
期数:
2012年02期
页码:
73-78
栏目:
出版日期:
2012-03-30

文章信息/Info

Title:
Research progress on microbial fermentation of L-lysine
文章编号:
1672-3678(2012)02-0073-06
作者:
张军华
中粮生化(安徽)股份有限公司,蚌埠233010
Author(s):
ZHANG Junhua
COFCO Biochemical (Anhui) Co., Ltd., Bengbu 233010, China
关键词:
L-赖氨酸生物合成调控育种
分类号:
TQ922+.3
DOI:
10.3969/j.issn.1672-3678.2012.02.015
文献标志码:
A
摘要:
微生物发酵法是目前生产L-赖氨酸最主要的方法。L-赖氨酸生物合成存在两个完全不同的途径:二氨基庚二酸途径和α氨基己二酸途径;分别由不同的酶进行调节,控制L赖氨酸的合成。笔者概述了L赖氨酸生产方法、生物合成途径以及合成中关键性酶的调节作用和国内外L赖氨酸生产菌育种方法的研究进展。

参考文献/References:

 [1]张伟国,陈银芳.L赖氨酸高产菌的选育及发酵培养基的优化[J].生物技术,2009,19(4): 36-40.

[2]Paegle L,Ruklisha M.Lysine synthesis control in Corynebaterium glutamicum Re115 in mixed substrate (glucoseacetate) medium[J].J Biotechnol,2003,104: 123-128.

[3]Wittmann C,Becker J.The Llysine story: from metabolic pathways to industrial production[J].Microbiol Monogr,2007,12(5): 39-70.

[4]Eggeling L,Sahm H.Lglutamate and Llysine: traditional products with impetuous developments[J].Appl Microbiol Biotechnol,1999,52: 146-153.

[5]许朝阳,朱敏宜,马杰.赖氨酸的生产及发展建议[J].安徽化工,2003,29(5):14-17.

[6]张伟国,顾正华. L赖氨酸高产菌选育的研究[J].食品与发酵工业,2001,27(8): 17-20.

[7]张伟国.L赖氨酸发酵的研究[J].发酵科技通讯,2005,34(1): 7-8.

[8]张久丽,胡耀辉.一株赖氨酸产生菌的菌种鉴定及发酵条件优化[D].长春:吉林农业大学,2008:3-5.

[9]Ikeda M.Amino acid production processes[J].Adv Biochem Eng Biotechnol,2003,79: 1-35.

[10]陈坚.发酵过程优化原理与实践[M].北京:化学工业出版社,2002:68-69.

[11]Wittmann C,Kim H M,Heinzle E.Metabolic network analysis of lysine producing Corynebacterium glutamicum at a miniaturized scale[J].Biotechnol Bioeng,2004,87: 1-6.

[12]Pfefferle W,Mockel B,Bathe B,et al.Biotechnological manufacture of lysine[J].Adv Biochem Eng Biotechnol,2003,79: 59-112.

[13]Takenouchi E,Yamamoto T,Nikolova D K,et al.Lysine production by S(2aminoethyl)Lcysteine resistant mutants of Candida pelliculosa[J].Agric Biol Chem,1979,43: 727-734.

[14]魏爱英,葛玉萍.L赖氨酸的代谢途径到工业生产[J].发酵科技通讯,2011,40(2):31-34.

[15]Haidaris C G,Bhattacharjee J K.High lysine excreting mutants of Saccharomyces cerevisiae[J].J Ferment Technol,1977,55(2): 189-192.

[16]Tosaka O,Takinami K,Hirose Y.Llysine production by S(2aminoethyl) Lcysteine and αaminoβhydroxyvaleric acid resistant mutants of Brevibacterium lactofermentum[J].Agric Biol Chem,1978,42: 745-752.

[17]Hermann T.Industrial production of amino acids by coryneform bacteria[J].J Biotechnol,2003,104(1/2/3): 155-172.

[18]杨迪,李艳,张喜红,等.重组苏云金芽胞杆菌丙酮酸脱氢酶克隆及表达条件的优化[J].化学与生物工程,2009,26(4): 39-42.

[19]Bartek T,Zonnchen E,Klein B,et al.Analysing over expressing of Lvaline biosysthesis genes in pyruvatedehydrogenasedeficient Corynbacterium glutamicum[J].J Ind Microbiol Biotechnol,2010,37(3):263-270.

[20]王绛,刘阳剑,王宇,等.钝齿棒杆菌CD945丙酮酸羧化酶基因的克隆、序列分析及表达[J].微生物学报,2003,43(2): 214-219.

[21]Lim F,Morris C P,Occhiodoro F,et al.Sequence and domain structure of yeast pyruvate carboxylase[J].J Biol Chem, 1988,263: 11493-11497.

[22]Wexler I D,Du Y,Lisgaris M V,et al.Primary amino acid sequence and structure of human pyruvate carboxylase[J].Biochim Biophys Acta,1994,1227: 46-52.

[23]Kumar G K,Haase F C,Phillips N F B,et al.Involvement and identification of a tryptophanyl residue at the pyruvate binding site of transcarboxylase[J].Biochem,1988,27: 5978-5983.

[24]Rylatt D B,Keech D B,Wallace J C.Pyruvate carboxylase: isolation of the biotincontaining tryptic peptide and the determination of its primary sequency[J].Arch Biochem Biophys,1977,183: 113-122.

[25]Leondel Rio A,Gravels R.A.Sequence requirements for the biotinylation of carboxylterminal fragments of human propionyCoA caboxylase α submit expressed in Escherichia coli[J].J Biol Chem,1994,269: 22964-22968.

[26]Eikmanns B J,Follettie M T,Griot M U,et al.The phosphonenolpyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning,nucleotide sequence and expression[J].Mol Gen Genet,1989,218: 330-339.

[27]赵艳,陈丽梅,李昆志.磷酸烯醇式丙酮酸羧化酶的分子结构研究进展[J].生物技术通报,2007(5): 9-13.

[28]Kalinowski J,Cremer J,Bachmann B,et al.Genetic and biochemical analysis of the aspartokinase from Corynebacterium glutamicum[J].Mol Microbiol,1991,5(5): 1197-1204.

[29]Kalinowski J,Bachmann B,Thierbach G,et al.Aspartokinase genes lysC alpha and lysC beta overlap and are adjacent to the aspartate betasemialdehyde dehydrogenase gene asd in Corynebacterium glutamicum[J].Mol Gen Genet,1990,224:317-324.

[30]Thierbach G,Kalinowski J,Bachmann B,et al.Cloning of a DNA fragment from Corynebacterium glutamicum conferring aminoethyl cysteine resistance and feedback resistance to aspartokinase[J].Appl Microbiol Biotechnol,1990,32:443-448.

[31]Sugimoto M,Tanaka A,Suzuki T,et al.Sequence analysis of functional regions of homoserine dehydrogenase genes from Llysine and Lthreonineproducing mutants of Brevibacterium lactofermentum[J].Biosci Biotechnol Biochem,1997,61:1760-1762.

[32]Cohen G N,Stanier R Y,Le Bras G.Regulation of the biosynthesis of the amio acids of aspartate family incoliform bacteria and Pseudomonads[J].J Bacteriol,1969,99:791-801.

[33]Vasicova P,Patek M,Nesvera J,et al.Analysis of the Corynebacterium glutamicum dapA promoter[J].J Bacteriol,1999,181:6188-6191.

[34]WolterinkVan Loo S,Levisson M,Cabrieres M C,et al.Characterization of a thermostable dihydrodipicolinate synthase from Thermoanaerobater tengcongensis[J].Extremophiles,2008,12(3):461-469.

[35]Vauterin M,Frankard V,Jacobs M.The Arabidopsis theliana dhdps gene encoding dihydrodipicolinate synthesis,key enzyme of lysine biosynthesis,is expressed in a cellspecific manner[J].Plant Mol Biol,1999,39(4):695-708.

[36]Kong Fanna,Jiang Shaomei,Meng Xiangbing,et al.Cloning and characterization of the DHDPS gene encoding the lysine biosynthetic enzyme dihydrodipocolinate synthase from Zizania latifolia (Griseb)[J].Plant Mol Biol Rep,2009,27(2):199-208.

[37]刘晓飞,高学军,刘营,等.微生物产赖氨酸的研究进展[J].东北农业大学学报,2010,41(1):157-160.

[38]Chaudhurl A,Ajit K,Nanda G.Lysine excretion by S(2aminoethyl) Lcysteine resistant mutants of Bacillus subtilis[J].Acta Microbiologica Polonica,1983,32:37-45.

[39]范长胜,陈力,郑善良.高产谷氨酸菌种转产赖氨酸的定向选育[J].微生物学杂志,1986,6(4): 11-16.

[40]GasentRamirez J M,Benitez T.Lysineoverproducing mutants of Saccharmyces cerevisiae baker’s yeast isolated in continuous culture[J].Appl Environ Microbiol,1997,63(12):4800-4806.

[41]潘中明,徐昀,应向贤.乳酸发酵短杆菌中的赖氨酸代谢控制发酵[J].粮食与饲料工业, 2000(5):26-27.

[42]齐秀兰,曾绍钧,周忠喜.L赖氨酸高产菌株的选育及发酵培养基优化[J].沈阳药科大学学报,2004,21(4):311-313.

[43]谢玉清,茆军,崔春生,等.L赖氨酸高产基因工程菌的构建[J].新疆农业科学,2003,40(2):123-124.

[44]王成华,刘宝胜,华威,等.二氢吡啶二羧酸合成酶基因在棒杆菌中的克隆与表达[J].山东化工,2005,34(3):18-21.

[45]Seibold G,Auchter M,Berens S,et al.Utilizaation of soluble starch by a recombinant Corynebacterium glutamicum strain: growth and lysine production[J].J Biotechnol,2006,124(2):381-391.

[46]董迅衍,徐大庆,李烨,等.乳糖发酵短杆菌lysC突变对L赖氨酸积累的影响[J].食品与生物技术学报,2011,30(4):592-596.

[47]Ohnishi J,Mitsuhashi S,Hayashi M,et al.A novel methodology employing Corynebacterium glutamicum genome information to generate a new Llysineproducing mutant[J].Appl Microbiol Biotechnol,2002,58(2): 217-223.

[48]饶志明,张君胜,沈微,等.谷氨酸棒杆菌高丝氨酸脱氢酶编码基因hom的敲除[J].中国生物工程杂志,2006,27(1):59-63.

[49]Liu D Y,Liu C H,Lai M T,et al.Global gene expression profiling of wild type and lysC knockout Escherichia coli W3110[J].FEMS Microbiol Lett,2007,276: 202-206.

[50]陆敏涛,赵智,张英姿,等.磷酸烯醇式丙酮酸羧化酶基因的敲除对北京棒杆菌PD67的生理代谢的影响[J].微生物学报,2010,50(10):1334-1340.


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备注/Memo

备注/Memo:
收稿日期:2011-09-06

基金项目:国家高技术研究发展计划(863计划)重大项目(2011AA02A205)

作者简介:张军华(1962—),男,山东寿光人,高级工程师,研究方向:生物工程,E-mail:zhang-junhua@cofco.com

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