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[1]郑裕国,金晓峰,郑仁朝,等.一类生物催化剂——氰基耐受型腈水合酶[J].生物加工过程,2010,8(03):73-78.[doi:10.3969/j.issn.1672-3678.2010.03.015]
 ZHENG Yu-guo,JIN Xiao-feng,ZHENG Ren-chao,et al.A class of biocatalyst: cyanide-resistant nitrile hydratase[J].Chinese Journal of Bioprocess Engineering,2010,8(03):73-78.[doi:10.3969/j.issn.1672-3678.2010.03.015]
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一类生物催化剂——氰基耐受型腈水合酶
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《生物加工过程》[ISSN:1672-3678/CN:32-1706/Q]

卷:
8
期数:
2010年03期
页码:
73-78
栏目:
出版日期:
2010-05-30

文章信息/Info

Title:
A class of biocatalyst: cyanide-resistant nitrile hydratase
文章编号:
1672-3678(2010)03-0073-06
作者:
郑裕国金晓峰郑仁朝林志坚沈寅初
浙江工业大学 生物工程研究所,杭州310014
Author(s):
ZHENG Yu-guoJIN Xiao-fengZHENG Ren-chaoLIN Zhi-jian SHEN Yin-chu
Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310014,China
关键词:
腈水合酶氰基耐受性α-羟基腈α-氨基腈
分类号:
Q557
DOI:
10.3969/j.issn.1672-3678.2010.03.015
文献标志码:
A
摘要:
氰基耐受型腈水合酶是一类生物催化剂。与普通腈水合酶相比,它能够耐受体系中较高浓度的氰基而不受抑制,从而为α-羟(氨)基酰胺的工业化合成开辟了崭新途径。研究腈水合酶的氰基耐受性机理及提高其耐受能力是目前需要解决的关键问题。综述了腈水合酶受氰基抑制的机制,氰基耐受型腈水合酶的发现以及其在蛋氨酸和2-羟基异丁酰胺生物合成中的应用。同时,对今后氰基耐受型腈水合酶基础、应用研究的思路进行了探讨。


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备注/Memo

备注/Memo:
收稿日期:2010-01-06
基金项目:国家重点基础研究发展计划(973计划)资助项目(2009CB724704);浙江省自然科学基金资助项目(Y4080334)
作者简介:郑裕国(1961—),男,浙江象山人,教授,研究方向:生物催化与生物转化,E-mail:zhengyg@zjut.edu.cn


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